This paper develops a novel framework to compute a projected Generalized Stein Unbiased Risk Estimator (GSURE) for a wide class of sparsely regularized solutions of inverse problems. This class includes arbitrary convex data fidelities with both analysis and synthesis mixed ℓ1 − ℓ2 norms. The GSURE necessitates to compute the (weak) derivative of a solution w.r.t. the observations. However, as the solution is not available in analytical form but rather through iterative schemes such as proximal splitting, we propose to iteratively compute the GSURE by differentiating the sequence of iterates. This provides us with a sequence of differential mappings, which, hopefully, converge to the desired derivative and allows to compute the GSURE. We illustrate this approach on total variation regularization with Gaussian noise to automatically select the regularization parameter.